Insulin-Like Growth Factors in the Peripheral Nervous System
نویسندگان
چکیده
منابع مشابه
Current Knowledge on Growth Hormone and Insulin-Like Growth Factors and their Role in the Central Nervous System
GH mediates most of its effects by releasing insulin-like growth factor-1 (IGF-1) through stimulation of GH receptors (GHR), in particular in the liver. Both GH and IGF-1 are shown to cross the blood-brain barrier (BBB) and affect specific targets for these hormones in the brain. The discovery of GH and IGF-1 receptors in the CNS and their distribution in brain areas associated with the functio...
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Introduction: Bechcet’s disease (BD) is a chronic disease with multiple organ involvement such as central nervous system (CNS) and peripheral nervous system (PNS). Involvement of PNS has been reported controversially and uncommon in textbooks and literatures. The aim of this study in to evaluate the auxiliary role of electrodiagnosis in early detection of PNS involvement to prevent neuropathy...
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Over the past decade, dozens of epidemiological studies and laboratory experiments have provided evidence for relationships between insulin-like growth factor (IGF) physiology and neoplasia. Population studies provide evidence for a modestly increased risk of a subsequent cancer diagnosis in subjects with IGF-I levels at the high end of the broad normal range, as compared to those at the low en...
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Bone alters its metabolic and anabolic activities in response to the variety of systemic and local factors such as hormones and growth factors. Classical observations describing abundance of the nerve fibers in bone also predict a paradigm that the nervous system influences bone metabolism and anabolism. Since 1916 several investigators tried to analyze the effect of peripheral nervous system i...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2008
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2008-1020